Assess if improving individual at high risk of HIV infection can improve the efficiency of future HPTN trials such as HVTN 703/HPTN 081 and others by reducing trial duration and biases due to frailty selection.
We develop an individual based trial simulator to assess whether enrolling larger proportion of participants with consistently high exposure to HIV, such as female sex workers (FSWs), might reduce trial duration and improve the accuracy of product efficacy estimates in future HIV prevention trials.
PI of HPTN:
Myron S Cohen (UNC)
Mathematical modellers and epidemiologists:
Daniel Wood (FHCRC)
Kathryn E. Lancaster (UNC)
Kimberly A. Powers (UNC)
Deborah Donnell (SCHARP)
The HPTN Modelling Centre, which is funded by the U.S. National Institutes of Health (NIH UM1 AI068617) through HPTN funded this work.