Primary Objective of HPTN 067:
To test the hypothesis that recommending intermittent (non-daily) usage of oral FTC/TDF chemoprophylaxis, compared with recommending daily usage, will be associated with:
- Equivalent coverage of sex events with pre- and post-exposure dosing
- Lower number of pills needed for coverage and fewer pills used
- Decreased self-reported symptoms/side effects (both severity and frequency) during 24 weeks of self-administered use
To develop new mathematical models using HPTN 067 data to assess the impact and cost-effectiveness of intermittent(non-daily) usage of oral FTC/TDF in different risk population and settings.
Robert M. Grant, MD, MPH
Gladstone Institute of Virology and Immunology
Associate Professor of Medicine, University of California, San Francisco
Frits van Griensven, PhD, MPH
Associate Professor of Epidemiology and Biostatistics, University of California, San Francisco
The HPTN Modelling Centre, which is funded by the U.S. National Institutes of Health (NIH UM1 AI068617) through HPTN fully funded this work.