The primary objectives of HPTN 078 are to:
• Assess the ability of DC-RDS to identify and recruit HIV-infected MSM in the US who are not virally suppressed.
• Compare the efficacy of the two study arms (CM intervention vs. SOC control) in achieving durable viral suppression (defined as HIV VL < 200 copies/ml) 24 months after enrollment.
Develop, calibrate, and use a mathematical model of HIV transmission among MSM in the US to assess the short and long-term population-level impact of the study strategy, and its independent CM intervention components (e.g., HIV testing, ART uptake, retention in care and viral suppression), on HIV incidence and to estimate the level of viral suppression required to reduce HIV incidence in the MSM community by 10%, 20%, 30%, and 50% over 2, 5 and 10 years, and the likelihood of and time to elimination.
Chris Beyrer, MD, MPH
Professor of Epidemiology, International Health, and Health, Behavior and Society
Director, Center for Public Health and Human Rights
Associate Director, Johns Hopkins Center for AIDS Research
Johns Hopkins University
Robert H. Remien, PhD
Professor of Clinical Psychology (in Psychiatry)
Director, HIV Center for Clinical and
Associate Director, Division of Gender,
Sexuality and Health, NY State Psychiatric
Institute and Columbia University
The HPTN Modelling Centre, which is funded by the U.S. National Institutes of Health (NIH UM1 AI068617) through HPTN fully funded this work.